Antiviral Drugs: From Basic Discovery Through Clinical Trials
Publisher: W ey 2011 ISBN: 0470455632 480 pages PDF 18,8 MB
A complete,onestop reference to realworld antiviral drug discovery and development
The field of antiviral drugs continues to evolve at a fast pace in response tonew virus discoveries and development of viral resistance to existing therapies. This book provides case histories and arms both basic and industrialpharmaceutical researchers with practical tools to tackle the ongoing challenges of antiviral drug design, discovery, and development.
Written byleading authorities from academia and industry, Antiviral Drugs compiles information previously scattered across the literature into one complete,selfcontained volume, unlike any other book on the subject. The authors draw on their own extensive research experience to present numerous case studiesillustrating the full drug design process, from bench to clinic, with special emphasis on proven strategies for the development of drugs against all majorviral infectious diseases, including HIV, HCV, RSV, influenza, HBV, and CMV.
Readers will find everything they need to analyze, understand, and applydiscovery and development principles, including:
Coverage of newly approved antiviral drugs and compounds in clinical development
Emphasis onnovel experimental molecules used to combat viral infections
Viral inhibitory mechanistic information
Clear examples for how to bring drugs fromlaboratory discovery to clinical trials
Effective examples and strategies of lead optimization yielding molecules of clinical value
Practicalsolutions for issues such as pharmacokinetics, viral resistance, and more
Key and specific references for readers wishing to explore the topicsfurther
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